Maternal asthma and newborn DNA methylation.

ABSTRACT:

Background

Prenatal exposure to maternal asthma may influence DNA methylation patterns in offspring, potentially affecting their susceptibility to later diseases including asthma.

Objective

To investigate the relationship between parental asthma and newborn blood DNA methylation.

Methods

Epigenome-wide association analyses were conducted in 13 cohorts on 7433 newborns with blood methylation data from the Illumina450K or EPIC array. We used fixed effects meta-analyses to identify differentially methylated CpGs (DMCs) and comb-p to identify differentially methylated regions (DMRs) associated with maternal asthma during pregnancy and maternal asthma ever. Paternal asthma was analyzed for comparison. Models were adjusted for covariates and cell-type composition. We examin

SUBMITTER: Pedersen CT 

PROVIDER: S-EPMC12065361 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature