Prognostic value of functional CT imaging in COVID-ARDS: a two-centre prospective observational study.

ABSTRACT:

Background

Patients with ARDS have heterogeneous lungs which exposes them to the risk of lung injury exacerbation by mechanical ventilation. Functional lung CT imaging gives a comprehensive description of regional lung mechanical behaviour. Here, we investigated whether CT registration-based regional lung function parameters are associated with survival in patients with COVID-ARDS.

Methods

We conducted a two-centre prospective observational study of adult COVID-ARDS patients with an indication for CT within 72 h of onset. Dual volume CT images were aligned using image-registration. Regional lung functional parameters, and their spatial distributions, were analysed by univariable Cox proportional hazard models with survival as the main outcome. Selected variables based on the

SUBMITTER: Shekarnabi M 

PROVIDER: S-EPMC12065372 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature