Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma.

ABSTRACT:

Background

C-X-C motif chemokine ligand 13 (CXCL13) is a crucial chemokine for the recruitment of immune cells and the formation of tertiary lymphoid structure (TLS) in the tumor microenvironment. However, the relationship between CXCL13 and immune infiltration in cutaneous squamous cell carcinoma (cSCC) remains unclear.

Objective

We aimed to investigate the expression of CXCL13 and explore its association with immune activation and TLS in cSCC.

Methods

A total of 63 cSCC patients were involved in the present study. Hematoxylin and eosin staining was used for pathological examination of cSCC. Bioinformatics analyses and immunohistochemical staining were employed to access the expression of CXCL13 and TLS states. Public single cell RNA-sequencing atlas of skin disorder

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12065455 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature