Trends in Psoriatic Arthritis Management From 1993 to 2019: Rise of Biologics and Decline of Oral Small Molecules.

ABSTRACT:

Background

Traditional oral small molecule disease-modifying antirheumatic drugs (OSMs) have historically been the cornerstone of psoriatic arthritis (PsA) management. However, biologics have gained prominence due to their superior efficacy in patients with an inadequate response to OSMs.

Objective

To analyze trends in the use of OSMs, biologics, and combination therapy for PsA management from 1993 to 2019.

Methods

We utilized the National Ambulatory Medical Care Survey to examine PsA treatment patterns. Medications were classified as OSMs, biologics, or combination therapy (both an OSM and a biologic). Weighted Rao-Scott χ² tests and one-way ANOVA assessed differences in treatment patterns over time and by patient demographics.

Results

Among an esti

SUBMITTER: Woodie BR 

PROVIDER: S-EPMC12065707 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature