Composition and Neurogenetic Effects of Embryonic Cerebrospinal Fluid: A Systematic Review.

ABSTRACT: Embryonic cerebrospinal fluid (E-CSF) has an important role in neurological development. Due to limited availability, the composition and properties of E-CSF are not known to the present. Our review aims to offer a comprehensive perspective over the studies published to date regarding the composition and effects of E-CSF. We performed a systematic search of four databases for studies regarding normal E-CSF, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We screened 725 records for eligibility criteria, resulting in 44 studies included in the narrative synthesis. Of these, four compared E-CSF with postnatal CSF, and three studies used human E-CSF for composition description. The most comprehensive set of molecular analyses was perfor

SUBMITTER: Beldean AC 

PROVIDER: S-EPMC12065756 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature