Recommendations for sample selection, collection and preparation for NMR-based metabolomics studies of blood.

ABSTRACT:

Background

Metabolic profiling of blood metabolites, particularly in plasma and serum, is vital for studying human diseases, human conditions, drug interventions and toxicology. The clinical significance of blood arises from its close ties to all human cells and facile accessibility. However, patient-specific variables such as age, sex, diet, lifestyle and health status, along with pre-analytical conditions (sample handling, storage, etc.), can significantly affect metabolomic measurements in whole blood, plasma, or serum studies. These factors, referred to as confounders, must be mitigated to reveal genuine metabolic changes due to illness or intervention onset.

Review objective

This review aims to aid metabolomics researchers in collecting reliable, standardized datasets f

SUBMITTER: Emwas AH 

PROVIDER: S-EPMC12065766 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature