Alterations in visible light exposure modulate platelet function and regulate thrombus formation.

ABSTRACT:

Background

Variations in light exposure are associated with changes in inflammation and coagulation. The impact of light spectra on venous thrombosis (VT) and arterial thrombosis is largely unexplored.

Objectives

To investigate the impact of altering light spectrum on platelet function in thrombosis.

Methods

Wild-type C57BL/6J mice were exposed to ambient (mice^white, 400 lux), blue (mice^blue, 442 nm, 1400 lux), or red light (mice^red, 617 nm, 1400 lux) with 12:12 hour light:dark cycle for 72 hours. After 72 hours of light exposure, platelet aggregation, activation, transcriptomic, and metabolomic changes were measured. The ability of released products of platelet activation to induce thrombosis-generating neutrophil extracellular trap f

SUBMITTER: Andraska EA 

PROVIDER: S-EPMC12066021 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature