Causal relationship between plasma lipidome and rosacea: a Mendelian randomization analysis.

ABSTRACT:

Background

Rosacea is a common chronic inflammatory skin disease. Limited studies reported the association between plasma lipidome and rosacea.

Methods

We employed a two-sample Mendelian randomization (MR) study to assess the causality between plasma lipidome and rosacea. Plasma lipidome association genome-wide association study (GWAS) data were collected. The inverse variance weighted (IVW) method was utilized as the principal method in our Mendelian randomization (MR) study; we also used the MR-Egger, weighted median, simple mode, and weighted mode methods. The MR-Egger intercept test, Cochran's Q test, MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and leave-one-out analysis were conducted to identify heterogeneity and pleiotropy.

Results

A total of 179 lipid

SUBMITTER: Wang X 

PROVIDER: S-EPMC12066300 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature