CD8+ T cell activation in endometrial cancer: prognostic implications and potential for personalized therapy.

ABSTRACT:

Background

As an important component in preventing the progression of endometrial cancer, CD8 T cells play a crucial role in this process and are important targets for immunotherapy. However, the status of CD8+ T cells in endometrial cancer and the key genes influencing their activation still remain to be elucidated.

Methods

Genes associated with the activation of CD8+ T cells were identified through differential analysis and weighted gene co-expression network analysis (WGCNA). A risk score model was constructed using the least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression. The clinical characteristics and differences between the high-risk group and the low-risk group were explored, and the applicability of the model to chemotherapy, poly

SUBMITTER: Guan H 

PROVIDER: S-EPMC12066579 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature