DNA methylation-driven genes in hepatocellular carcinoma patients: insights into immune infiltration and prognostic implications.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) poses a significant global burden as a highly prevalent and life-threatening malignant tumor that endangers human life and wellbeing. The purpose of this study was to examine how DNA methylation-driven genes impact the prognosis of HCC patients.

Methods

Differentially expressed genes from The Cancer Genome Atlas, GSE76427, GSE25097 and GSE14520 datasets were collected to perform differential expression analysis between HCC patients and controls. Weighted gene coexpression network analysis (WGCNA) was subsequently performed to create coexpression modules for the DEGs. Then, ssGSEA was employed to investigate the infiltration of immune cells in HCC. Enrichment analysis and methylation were carried out for the module genes. We utilized

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12066630 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature