Reduced finger tapping speed in patients with schizophrenia and psychomotor slowing: an exploratory fMRI study.

ABSTRACT:

Introduction

Motor symptoms are frequent in patients with schizophrenia and have multiple presentations, one of which is psychomotor slowing. Understanding the neural basis of psychomotor slowing may help improve future therapies in schizophrenia. Here, we performed task-fMRI using a finger-tapping task in slowed patients.

Methods

The study included 36 patients with schizophrenia and psychomotor slowing (Salpêtrière-Retardation-Rating-Scale-Score (SRRS) >15), 11 non-slowed patients with schizophrenia, and 33 healthy controls who successfully performed a motor task during fMRI, with four conditions: paced and fast thumb-index finger tapping and thumb alternating finger opposition. The performance was videotaped and taps were counted. We compared task-related neural substrates

SUBMITTER: Wuthrich F 

PROVIDER: S-EPMC12066633 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature