Genetic Variation in Drug Targets: Are We Ready for the Era of Precision Medicinal Chemistry?

ABSTRACT: Natural genetic variations profoundly impact drug target interactions causing variations in in vitro biological data. The overall occurrence or "rare genetic variation" is common and enriched within population groups. Incorporating population-level genetic information earlier into the drug discovery pipeline would allow medicinal chemists to contribute to the precision medicine movement, designing drugs with more population relevance.

SUBMITTER: Veale CGL 

PROVIDER: S-EPMC12067103 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature