Detecting DNA translocation through a nanopore using a van der Waals heterojunction diode.

ABSTRACT: A long-unrealized goal in solid-state nanopore sensing is to achieve out-of-plane electrical sensing and control of DNA during translocation, which is a prerequisite for base-by-base ratcheting that enables DNA sequencing in biological nanopores. Two-dimensional (2D) heterostructures, with their capability to construct out-of-plane electronics with atomic layer precision, are ideal yet unexplored candidates for use as electrical sensing membranes. Here, we demonstrate a nanopore architecture using a vertical 2D heterojunction diode consisting of p-type WSe₂ on n-type MoS₂. This diode exhibits rectified interlayer tunneling currents modulated by ionic potential, while the heterojunction potential reciprocally rectifies ionic transport through the nanopore. We achieve c

SUBMITTER: Chen S 

PROVIDER: S-EPMC12067215 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature