Understanding TAK1 deficiency in microglia: Dual mechanisms for photoreceptor protection in a mouse model of retinitis pigmentosa.

ABSTRACT: Retinitis pigmentosa (RP) is a group of inherited retinal diseases characterized by the progressive loss of photoreceptors. Neuroinflammation has been implicated in the pathophysiology of RP and its progression. Previous studies have suggested that the transforming growth factor-beta-activated kinase 1 (TAK1) plays a pivotal role in regulating acute and chronic neuroinflammation. However, the functional role of TAK1 in neuroinflammation remains unclear in RP. Here, we observed TAK1 upregulation in activated microglia of the rd10 mouse model of RP. To create the conditional deletion of TAK1 in microglia, we backcrossed Cx3cr1^CreER/CreER mice and Tak1^fl/fl mice onto rd10 background. We found that both heterozygous (rd10;Cx3cr1^CreER/+;Tak1^fl/+) and

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12067235 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature