Association of Inherited Genetic Variants with Multiple Primary Melanoma.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS) have identified new susceptibility loci for melanoma, but their associations with multiple primary melanoma (MPM) are unclear.

Methods

We investigated the associations of 69 SNPs in 39 GWAS-identified loci with odds of MPM relative to single primary melanoma in the international, population-based Genes, Environment, and Melanoma study. Per-minor-allele ORs and 95% confidence intervals (CI) for individuals with MPM "cases" (n = 1,205) relative to single primary melanoma "controls" (n = 2,458) were estimated using multivariable logistic regression, and polygenic risk scores (PRS) were calculated and weighted based on a 2020 GWAS meta-analysis (57 of the 68 independent GWAS SNPs available).

Results

Thirteen SNPs in

SUBMITTER: Gibbs DC 

PROVIDER: S-EPMC12067251 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature