Closed-loop modulation of remote hippocampal representations with neurofeedback.

ABSTRACT: Humans can remember specific remote events without acting on them and influence which memories are retrieved based on internal goals. However, animal models typically present sensory cues to trigger memory retrieval and then assess retrieval based on action. Thus, it is difficult to determine whether measured neural activity patterns relate to the cue(s), the memory, or the behavior. We therefore asked whether retrieval-related neural activity could be generated in animals without cues or a behavioral report. We focused on hippocampal "place cells," which primarily represent the animal's current location (local representations) but can also represent locations away from the animal (remote representations). We developed a neurofeedback system to reward expression of remote representations a

SUBMITTER: Coulter ME 

PROVIDER: S-EPMC12067296 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature