Size-Dependent Interactions of Degraded PET Nanoparticles with Human Serum Albumin: Thermodynamic and Molecular Insights.

ABSTRACT: This study examines the interaction between degraded polyethylene terephthalate (PET) nanoparticles and human serum albumin (HSA), focusing on the effects of nanoparticle size and surface modifications resulting from degradation. PET degradation, induced via shock compression in water, leads to significant chemical alterations, including the formation of hydroxyl, carboxyl, and carbonyl groups. These modifications influence the hydrophilicity of PET nanoparticles and their binding behavior with HSA. The production of degraded PET nanoparticles involves subjecting pristine PET to controlled shock compression in an aqueous environment, which initiates chemical reactions similar to those that may occur during degradation. The degradation process is characterized by a progressive breakdown of

SUBMITTER: Panczyk T 

PROVIDER: S-EPMC12067432 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature