Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study.

ABSTRACT:

Objectives

Cellular senescence, characterized by a marked and multifactorial senescence-associated secretory phenotype (SASP), is a potential unifying mechanism of aging and chronic disease. Most studies of the SASP have focused on frailty and other functional outcomes. Senescent cells have been detected in the brains of patients with Alzheimer's disease, but few studies have examined associations between plasma SASP markers and cognition. The objective of this study was to examine the cross-sectional and longitudinal associations between plasma SASP markers and mild cognitive impairment among older adults at high risk of mobility disability.

Design

The Lifestyle Interventions for Elders (LIFE) study was a randomized controlled trial of a group-based physical activity progra

SUBMITTER: Mielke MM 

PROVIDER: S-EPMC12067485 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature