Histotripsy of the Proximal Ureter and Renal Pelvis: Evaluation of Urothelial Injury in a Porcine Survival Model.

ABSTRACT:

Purpose

To evaluate the response of the ureter and renal pelvis to direct targeting by histotripsy guided by cone-beam computed tomography (CT) in a human-scale porcine chronic-survival model.

Materials and methods

Bilateral ureteral histotripsy treatments were completed on 6 female swine (n = 12). Animals were divided into 2 groups: (a) acute (n = 2 animals, 4 treatments, sacrificed at Day 0) and (b) chronic (n = 4 animals, 8 treatments, sacrificed at Day 7 [n = 2] and Day 28 [n = 2]). For each treatment, a 2.5-cm sphere (ureter/renal pelvis and renal parenchyma) was targeted using cone-beam CT guidance. CT urography imaging was performed immediately after treatment for all animals, and on Days 7 and 28 for chronic animals, followed by sacrifice, necropsy, and histopatholog

SUBMITTER: Kisting AL 

PROVIDER: S-EPMC12067682 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature