Vitamin D status, vitamin D receptor polymorphisms, and risk of cardiometabolic multimorbidity.

ABSTRACT:

Background

The prevalence of cardiometabolic multimorbidity (CMM) has increased substantially in recent years. Previous studies have established the associations between vitamin D, vitamin D receptor (VDR) polymorphisms, and the risk of individual cardiometabolic disease (CMD). However, the role of these factors in the progression of CMD to CMM or mortality remains unclear. This study aimed to investigate the associations between vitamin D, VDR polymorphisms, and the dynamic progression of CMM, as well as to explore the potential modification effect of VDR polymorphisms.

Methods

Data for this cohort study were extracted from the UK Biobank. CMM was defined as the coexistence of at least two CMDs, including type 2 diabetes (T2D), coronary heart disease (CHD), and stroke. A mu

SUBMITTER: Ma J 

PROVIDER: S-EPMC12067687 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature