The interictal transcriptomic map of migraine without aura.

ABSTRACT:

Background

The present study aimed to deliver a replicable transcriptomic map of migraine without aura (MO) and its comprehensive, genome- and drug discovery focused analysis to identify hypotheses for future research- and clinical attempts.

Methods

We recruited 30 controls and 22 MO patients without serious chronic comorbidities/regular medication intake. RNA-sequencing was conducted interictally at two different time points to identify replicable differential gene expression and enriched pathways. Subsequent refining and functional analyses were performed, including: 1) testing additional patient factors, 2) running genetic association analysis on migraine in the UK Biobank (UKB) and our cohort, and 3) predicting drug binding with AutoDock Vina and machine learning to prot

SUBMITTER: Petschner P 

PROVIDER: S-EPMC12067696 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature