Post-genome-wide association study dissects genetic vulnerability and risk gene expression of Sjogren's disease for cardiovascular disease.

ABSTRACT:

Objectives

This study aims to clarify the genetic associations between Sjögren's Disease (SD) and cardiovascular disease (CVD) outcomes, and to conduct an in-depth exploration of specific pleiotropic susceptibility genes.

Methods

We performed two-sample and multivariable Mendelian randomization (MR) analysis to investigate the association between SD and the risk of ischemic heart disease (IHD) and stroke. Linkage disequilibrium score regression (LDSC) and Bayesian co-localization analyses were employed to assess the genetic associations between traits. Cross-phenotype analyses were employed to identify shared variants and genes, followed by a Transcriptome-Wide Association Study (TWAS) and Multi-marker Analysis of Genomic Annotation (MAGMA) based on Multi-Trait Analysis of G

SUBMITTER: Yi X 

PROVIDER: S-EPMC12067732 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature