Copper's new role in cancer: how cuproptosis-related genes could revolutionize glioma treatment.

ABSTRACT:

Objectives

Cuproptosis, a novel form of regulatory cell death, was investigated in this study for its effects on cuproptosis-associated proteins during gliomas development, offering novel insights into the mechanism of copper ion-based antitumor drugs.

Methods

In the present study, bioinformatics and cellular experiments were employed to investigate cuproptosis-related genes (CRGs) in glioma, with a specific focus on SLC31A1.

Results

The study findings indicated that many CRGs (SLC31A1, FDX1, DLST, LIPT1, LIPT2, DLD, NFE2L2, ATP7A, DLAT, GCSH, and ATP7B) were differentially expressed between glioma and non-tumor groups. These genes potentially influence glioma initiation and progression by modulating associated signaling pathways, including those involved in cell cycl

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12067758 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature