Platelet-Released Growth Factors (PRGFs) Activate NRF2-ARE and Modulate Inflammatory Response in an NRF2-Dependent Manner in Primary Human Keratinocytes.

ABSTRACT:

Background

Platelet-released-growth factors (PRGF) and platelet-rich plasma (PRP) are blood-derived products used in regenerative treatments and in overall aesthetic rejuvenation. Keratinocytes possess distinctive characteristics responsible for protection against environmental stressors and oxidant clearance. One such mechanism is the transcription factor NRF2, which plays a critical role in regulating cytoprotective genes, inflammation, and oxidative stress response. Data on the activation of the NRF2-ARE and NF-κB axes by PRGF are very limited.

Aim

This study aims to investigate whether PRGF activates NRF2 and, if so, is responsible for the described anti-inflammatory effect of PRGF/PRP in an in vitro primary human keratinocyte model.

Methods

NRF2 activation is ana

SUBMITTER: Stein M 

PROVIDER: S-EPMC12067853 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature