Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma.

ABSTRACT: Replication stress exerts an important role in fueling genomic instability characterizing multiple myeloma (MM) evolution and is a leading cause of drug resistance. Normal and malignant plasma cells (PCs) are associated with a high transcriptional stress due to the huge production of immunoglobulins. Transcription-replication conflicts (TRCs), arising from collisions between replication and transcription machineries, can promote tumor progression and represent an Achilles' heel to cancer cells. We reported a gene signature related to TRCs management (TRC score), overexpressed in malignant vs normal PCs. High TRC score identified patients with MM with a poor prognosis who could benefit from a TRC-enhancing therapy, in independent cohorts of patients with MM treated with high-dose melphalan

SUBMITTER: Dutrieux L 

PROVIDER: S-EPMC12067907 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature