A pragmatic randomized trial to compare strategies for implementing primary HPV testing for routine cervical cancer screening in a large healthcare system.

ABSTRACT:

Background

Recent updates to national guidelines recommend primary human papillomavirus (HPV) screening for routine cervical cancer screening alongside previously recommended screening options. However, limited guidance exists for implementation approaches that best facilitate cancer screening practice substitution and achieve optimal stakeholder-centered outcomes. We compared "centrally-administered + locally-tailored" (here after referred to as locally-tailored) vs. "centrally-administered + usual care" (here after referred to as centrally-administered) approaches for achieving substitution of HPV and cytology co-testing with primary HPV screening for routine cervical cancer screening to examine the effect of local tailoring on implementation and stakeholder-centered outcomes.

SUBMITTER: Chao CR 

PROVIDER: S-EPMC12067918 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature