Bioinformatics-guided decoding of the Ancylostoma duodenale genome for the identification of potential vaccine targets.

ABSTRACT: Ancylostoma duodenale, a parasitic nematode worm, is found to be involved in various infections, including intestinal blood loss, protein malnutrition, and anemia. Antimicrobial resistance to the available therapeutics has prompted the search for new drug and vaccine targets against A. duodenale. Despite significant advances in vaccine development against A. duodenale, no commercial and FDA-approved vaccine exists to safeguard humans from infections caused by this pathogen. In this investigation, a stringent bioinformatics analysis identified 36 unique essential and host-interacting proteins. Based on their subcellular localization, 6 proteins located in the extracellular space and outer membrane were categorized as vaccine targets, while the remaining proteins were predicted to act as pot

SUBMITTER: Shah M 

PROVIDER: S-EPMC12067957 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature