Kansui-liquorice enhances the "water-expelling" effect of Gansui Banxia decoction in rats with malignant ascites by targeting the NPs/NPRs/cGMP/PKGⅡ pathway and T cell immunity.

ABSTRACT:

Ethnopharmacological relevance

The combination of Euphorbia kansui Liou ex S.B.Ho (kansui) and Glycyrrhiza uralensis Fisch (liquorice) is contraindicated in Chinese medicine, but whether it can be used in clinical practice remains controversial. The classic formula, Gansui Banxia decoction (GBD), contains kansui and liquorice, which is effective in treating an abnormal accumulation of body fluids, such as malignant ascites (MA); however, the contraindications of kansui and liquorice have limited its clinical application.

Aim of the study

This study aims to provide a theoretical basis for the rational application of kansui-liquorice by investigating its role and mechanism in GBD.

Materials and methods

LC-MS/MS was used to detect the metabolic differences

SUBMITTER: Huo M 

PROVIDER: S-EPMC12067993 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature