Repeatability, reliability, and stability of eye movement measurements in Parkinson's disease, cerebellar ataxia, and healthy adults.

ABSTRACT:

Introduction

Eye movements have been proposed as biomarkers to track disease progression and treatment effects in neurological diseases. Before such variables are used in the clinic or in drug trials, properties such as measurement error must be documented. In this study, we assessed repeatability, reliability, and stability of fixation, smooth pursuit, and saccade measurements in patients with Parkinson's disease, cerebellar ataxia, and healthy adults.

Methods

Fixation, smooth pursuit, and saccade metrics were measured in 16 patients with Parkinson's disease, 16 patients with ataxia, and 25 healthy adults with an eye tracker (BulbiCam). The same operator repeated the measurements six times over 2 days in the patient group and two times the same day in the healthy adults. Re

SUBMITTER: Dalbro SEJ 

PROVIDER: S-EPMC12068062 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature