Methicillin-sensitive <i>Staphylococcus aureus</i> lineages contribute towards poor patient outcomes in orthopaedic device-related infections.

ABSTRACT: Staphylococci are the most common cause of orthopaedic device-related infections (ODRIs), with Staphylococcus aureus responsible for a third or more of cases. This prospective clinical and laboratory study investigated the association of genomic and phenotypic variation with treatment outcomes in ODRI isolates. Eighty-six invasive S. aureus isolates were collected from patients with ODRI, and clinical outcome was assessed after a follow-up examination of 24 months. Each patient was then considered to have been 'cured' or 'not cured' based on predefined clinical criteria. Whole-genome sequencing and molecular characterization identified isolates belonging to globally circulating community- and hospital-acquired lineages. Most isolates were phenotypically susceptible to methici

SUBMITTER: Post V 

PROVIDER: S-EPMC12068410 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature