Spatio-temporal distribution of Crimean-Congo Hemorrhagic Fever and its relationship with climate factors in Pakistan: A decade-long experience from tertiary care laboratory network.

ABSTRACT: Pakistan is at high-risk for Crimean-Congo Hemorrhagic Fever (CCHF) outbreaks due to its geographic location and disease burden in bordering countries. We aimed to study the spatio-temporal distribution of human CCHF cases in Pakistan and to observe its correlation with temperature, precipitation and seasonal variation. Retrospective data of test requests generated for CCHF at country-wide patient sample collection points (n = 307) across Pakistan from 2012 to 2023 was extracted for analysis. Average monthly temperature and precipitation data was used in the Poisson regression method to examine the effect on the number of cases. A total of 2,559 patients were clinically suspected of CCHF in 39 cities with 547 confirmed positive for CCHF in 10 cities using real-time PCR assay, with a positi

SUBMITTER: Abid MA 

PROVIDER: S-EPMC12068632 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature