Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.

ABSTRACT:

Introduction

Sleep dysfunction in those at higher risk of dementia may be associated with early structural changes to the hypothalamus.

Methods

We used multivariate regression to analyze self-reported sleep (Pittsburgh Sleep Quality Index [PSQI]) from cognitively healthy participants in the PREVENT Dementia and Alzheimer's and Families (ALFA) studies (n = 1939), stratified by apolipoprotein E (APOE) genotype as homozygotes, heterozygotes, and non-carriers. FreeSurfer was used to extract hypothalamic subunit volumes from T1-weighted magnetic resonance images.

Results

APOE ε4 homozygotes had a larger anterior-superior hypothalamus compared to heterozygotes and non-carriers, an effect which was driven by younger people in the cohort. APOE ε4 carriers had a higher PSQI gl

SUBMITTER: Laurell AAS 

PROVIDER: S-EPMC12069023 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature