Exploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implications.

ABSTRACT: Diabetes is a rapidly growing global health concern projected to affect one in eight adults by 2045, which translates to roughly 783 million people. The profound metabolic alterations often present in dysglycaemia significantly increase the risk of cardiovascular complications. While genetic susceptibility plays a crucial role in diabetes and its vascular complications, identifying genes and molecular mechanisms that influence both diseases simultaneously has proven challenging. A key reason for this challenge is the pathophysiological heterogeneity underlying these diseases, with multiple processes contributing to different forms of diabetes and specific cardiovascular complications. This molecular heterogeneity has limited the effectiveness of large-scale genome-wide association studies

SUBMITTER: Lee H 

PROVIDER: S-EPMC12069157 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature