Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.

ABSTRACT:

Aims/hypothesis

Glycaemic traits such as high fasting glucose levels and insulin resistance are positively associated with the risk of type 2 diabetes and other cardiometabolic diseases. Genetic association studies have identified hundreds of associations for each glycaemic trait, yet very few studies have involved continental African populations. We report the results of genome-wide association studies (GWASs) in a pan-African cohort for four glycaemic traits, namely fasting glucose, fasting insulin, insulin resistance (HOMA-IR) and beta cell function (HOMA-B), which are quantitative variables that affect the risk of developing type 2 diabetes.

Methods

GWASs for the four traits were conducted in approximately 10,000 individuals from the Africa Wits-INDEPTH Partnership for G

SUBMITTER: Chebii VJ 

PROVIDER: S-EPMC12069158 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature