Nanobiotic Formulations utilizing Quinoline-based-Triazole functionalized Carbon Quantum Dots via Click Chemistry for Combatting Clinical-Resistant Bacterial Pathogens.

ABSTRACT: Therapeutic options for preventing the trajectory of multi-drug resistance bacterial pathogens could rely on the effort to design a novel technique to develop a potent antimicrobial agent to counter the key issue. To curb the current outbreak, we synthesized first generation of antimicrobial amine-modified carbon quantum dots, CQDs-NH₂ as carbon precursors followed by hydrothermal carbonization of ethylenediamine/citric acid, and postmodified with propargyl alcohol (CQDs-1) and quinoline derivative; 8-hydroxy quinoline (CQDs-2) through Cu(I)-catalyzed azide-alkyne cycloaddition. The novel clicked 1,2,3-triazole functionalized CQDs-NH₂ templates, were evaluated against standard Gram-positive; Staphylococcus aureus (S. aureus), and Gram-negative; Escher

SUBMITTER: Yadav N 

PROVIDER: S-EPMC12069200 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature