Peak alpha frequency and alpha power spectral density as vulnerability markers of cognitive impairment in Parkinson's disease: an exploratory EEG study.

ABSTRACT:

Background

Cognitive impairment substantially impacts quality of life in Parkinson's disease (PD), yet current biomarker frameworks lack sensitivity for detecting early-stage cognitive decline. While peak alpha frequency (PAF) and alpha power spectral density (PSD) have emerged as potential electrophysiological markers, prior studies primarily focused on global cortical measures, neglecting region-specific variations that may better reflect the heterogeneous nature of PD-related cognitive impairment (PDCOG). To address this gap, we conducted the first multiregional comparative analysis of PAF and alpha PSD between PDCOG and PD with normal cognition patients (PDNC).

Methods

Data from 76 participants (44 PD, 32 healthy controls) at The Affiliated Rehabilitation Hospital of Fuj

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12069304 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature