Metabolomic and proteomic analyses of renal function after liver transplantation.

ABSTRACT:

Background

Renal dysfunction is a common and serious complication in patients with end-stage liver diseases. While some patients recover renal function after liver transplantation (LT), others do not. Additionally, patients with normal kidney function (Normal-KF) before LT may develop post-transplant renal dysfunction. Early identification of patients at risk for impaired kidney function (Impaired-KF) post-LT is critical to improving outcomes. This study integrated metabolomic and proteomic analyses to investigate molecular profiles distinguishing Normal-KF from Impaired-KF post-LT.

Methods

Nine LT recipients were classified into Normal-KF (n = 5) and Impaired-KF (n = 4) groups. One additional recipient with pre-transplant renal function impairment who recovere

SUBMITTER: Wang X 

PROVIDER: S-EPMC12069452 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature