The identification of a blood circular RNA signature that differentiates Chikungunya virus infection.

ABSTRACT:

Objective

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen, which poses critical threats to the public health. However, an effective diagnostic method for early CHIKV infection remains scarce. Circular RNAs (CircRNAs) are a novel class of RNAs with important biological functions. They have been shown to be promising biomarkers for many human diseases. In this study, we sought to identify circRNA biomarkers in human peripheral whole blood for the early diagnosis of CHIKV infection.

Design

Candidate circRNA biomarkers were identified by group comparison using a case-control study, which was further validated using an independent cohort. The performance of this signature and its correlation with clinical factors were estimated in both cohorts.

Results

SUBMITTER: Bai X 

PROVIDER: S-EPMC12069458 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature