Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes.

ABSTRACT:

Aims/hypothesis

The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas and other tissues from organ donors with type 1 diabetes. These analyses involved the largest number of pancreas samples collected to date. The aim of the current work was to examine the presence of enterovirus RNA in pancreas and lymphoid tissues of organ donors with and without type 1 diabetes.

Methods

We analysed pancreas, spleen, pancreatic lymph nodes and duodenum samples from the following groups: (1) donors with type 1 diabetes (n=71) with (n=35) or without (n=36) insulin-containing islets; (2) donors with single or double islet autoantibody positivity without diabetes (n=22); and (3) autoantibody-negative donors without diabetes (control d

SUBMITTER: Laiho JE 

PROVIDER: S-EPMC12069483 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature