Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [¹⁸F]FDG PET/CT in patients with type 2 diabetes.

ABSTRACT:

Background

Recently developed dynamic whole-body PET/CT (D-WB PET/CT) protocols allow for measurements of potentially more precise metabolic parameters than the commonly used semiquantitative SUV. Most notable is the metabolic rate of FDG uptake (MR_FDG), which reflects quantitative glucose uptake into tissues and organs. However, data on the reproducibility of MR_FDG measurements are scarce, particularly in patients with perturbed glucose homeostasis such as type 2 diabetes. We therefore aimed to evaluate the test-retest repeatability of both MR_FDG and SUV in these patients.

Results

Fifteen participants (mean age 71 ± 7 years; 2 females) with type 2 diabetes underwent a short 20-minute [¹⁸F]FDG D-WB PET/CT after 6 h fasting on two c

SUBMITTER: Baier JM 

PROVIDER: S-EPMC12069784 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature