Genomic Exploration of Nonalcoholic Fatty Liver Disease: Insights From Gene Expression and Variation in Morbidly Obese Individuals.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is a common liver condition resulting from metabolic syndrome characterized by fat accumulation in the liver. It is often associated with obesity and diabetes, contributing to hepatic steatosis in liver cells. The prevalence of NAFLD is increasing globally, with 32% of the adult population affected. Genetic modifiers, such as single nucleotide polymorphisms, can increase susceptibility to the disease. Gene expression analysis and genetic variation can help identify disease-causing pathways and reveal biomarkers involved in NAFLD. This study employed integrative bioinformatics analysis, including bulk RNA-seq and single-cell RNA-seq, to explore differentially expressed genes and their genetic variants in NAFLD vs. control and NAFLD vs. cirrhosis, hig

SUBMITTER: Rafaa TA 

PROVIDER: S-EPMC12069845 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature