Causal Relationship Between Gut Microbiota and Gastrointestinal Polyps: A Mendelian Randomization Study.

ABSTRACT:

Background/aims

Numerous studies have confirmed that intestinal flora is closely linked to the development of gastrointestinal polyps. However, the precise causal link between them has yet to be clarified. This study sought to determine the causal relationship between gut microbiota and gastric, duodenal, colon, and rectal polyps by Mendelian randomization (MR).

Materials and methods

We employed publicly available genome-wide association study summary data to conduct MR analysis. Gut microbiota data were sourced from the International MiBioGen Consortium, and gastrointestinal polyp data were obtained from the MRC-IEU Consortium. Instrumental variables were selected based on eligible single-nucleotide polymorphisms. To assess causality, we utilized MR-Egger, weighted median,

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12070428 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature