Towards a kingdom of reproductive life - the core sperm proteome.

ABSTRACT:

In brief

Sperm function is essential for fertility across humans, agriculture and wildlife, yet comparative studies remain limited. This study integrates multi-species proteomic data to identify a core sperm proteome, uncovering conserved molecular pathways and validating novel sperm proteins critical for motility and fertilization.

Abstract

Reproductive biology is often considered in three siloed research areas; humans, agriculture and wildlife. Yet, each demand solutions for treatment of subfertility, fertility biomarkers, development of assisted reproductive technologies and effective contraception. To efficiently develop solutions applicable to all species, we must improve our understanding of the common biology underpinning reproductive processes. Accordingly, we integr

SUBMITTER: Pini T 

PROVIDER: S-EPMC12070448 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature