The unique histidine kinase, AtcS, regulates motility and pathogenicity of the periodontal pathobiont, <i>Treponema denticola</i>.

ABSTRACT: Treponema denticola is an obligate colonizer of the human gingival crevice and, along with other pathobionts, is highly associated with the development of periodontal disease. As periodontal disease develops, significant environmental changes occur in the subgingival crevice and oral microbiome. The ability to sense and respond to changing environmental conditions is essential to the ability of T. denticola to thrive and cause disease. Yet, our understanding of T. denticola sensory transduction and gene regulatory mechanisms is nearly absent. The AtcSR two-component system has been predicted to regulate several cellular processes, but its role in T. denticola adaptive responses has not been investigated. To address this knowledge gap, we constructed a deletion o

SUBMITTER: Abdallah DN 

PROVIDER: S-EPMC12070737 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature