Neighborhood Disadvantage, Built Environment, and Breast Cancer Outcomes: Disparities in Tumor Aggressiveness and Survival.

ABSTRACT:

Background

Breast cancer disparities persist globally, with growing evidence implicating neighborhood and built environmental factors in disease outcomes.

Methods

This study investigates the associations between neighborhood disadvantage, environmental exposures, and breast tumor characteristics and survival among 3041 stage I-III breast cancer patients treated at the University of Virginia Comprehensive Cancer Center (2014-2024). Neighborhood disadvantage was assessed via the Area Deprivation Index (ADI), while environmental exposures included PM2.5, green space (NDVI), and food indices (modified retail food environment index (mRFEI), retail food activity index (RFAI)). Multivariable regression and Cox models adjusted for demographic, socioeconomic, and clinical covariates

SUBMITTER: Shen J 

PROVIDER: S-EPMC12070865 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature