Roles of Annexin A1 Expression in Small Cell Lung Cancer.

ABSTRACT:

Background/objectives

Small cell lung cancer (SCLC) is one of the malignancies with the worst prognosis, and there have been no major breakthroughs in its treatment for a long time. The majority of patients are diagnosed at the extensive stage, where the only option is chemotherapy, and even the addition of immune checkpoint inhibitors results in only modest benefits. The characterization of the molecular mechanisms behind therapy resistance has relevance in finding novel therapeutic approaches. Previous studies showed the possibility of annexin A1's (ANXA1) involvement in the immunosuppressive tumor microenvironment in SCLC, and there are studies showing the direct effects of ANXA1 modulation on cancer cell aggressiveness.

Methods

We aimed to characterize the roles of ANXA1

SUBMITTER: Paal A 

PROVIDER: S-EPMC12070913 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature