Negative Effect of Intravenous Antibiotics on Survival in Patients with Triple-Negative Breast Cancer.

ABSTRACT:

Background

The anti-tumor response of the immune system is pivotal for treating triple-negative breast cancer (TNBC), particularly as targeted therapies are limited. However, the impact of immune-modulating factors such as the application of granulocyte-stimulating factors (G-CSFs) or infections, including febrile neutropenia, prophylactic or therapeutical application of oral antibiotics (OABs), and the need for intravenous antibiotics (IABs), on survival outcomes remains unclear.

Methods

1583 patients with early-stage TNBC enrolled in the SUCCESS A or C study underwent primary surgery, adjuvant chemotherapy, and radiotherapy if indicated. All patients had Eastern Cooperative Oncology Group (ECOG) status ≤ 2. The effects of G-CSF, OAB, and IAB application on overall survival

SUBMITTER: Lukac S 

PROVIDER: S-EPMC12071010 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature