Study on γδT-Cell Degranulation at Maternal-Fetal Interface via iKIR-HLA-C Axis.

ABSTRACT: Maternal-fetal tolerance mechanisms are crucial during human pregnancy to prevent the immune rejection of the embryo. A well-known mechanism blocking NK-cell cytotoxicity is the interaction of their inhibitory killer-cell immunoglobulin-like receptors (iKIR) with HLA-C molecules on the target cells. In this study, we aimed to investigate the expression of iKIRs (KIR2DL1 and KIR2DL2/3) on the matched decidual and peripheral γδT cells and the localization of HLA-C ligands throughout human pregnancy. The degranulation of γδT cells of pregnant and non-pregnant women in the presence of trophoblast cells was evaluated as well. Our results showed a higher proportion of iKIR-positive γδT cells at the maternal-fetal interface early in human pregnancy compared to the paired blood of pregnant women a

SUBMITTER: Manchorova D 

PROVIDER: S-EPMC12071288 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature