Rs1051931 Nonsynonymous Polymorphism of Platelet-Activating Factor Acetylhydrolase Gene <i>PLA2G7</i> Is Associated with Dysesthesia and Pain Severity After Surgery.

ABSTRACT: Platelet-activating factor (PAF) is a potent inflammatory mediator that activates the PAF receptor, which induces additional PAF production. Animal studies have shown that PAF induces inflammatory and neuropathic pain, including dysesthesia, a prodromal symptom of neuropathic pain. However, in humans, the association between PAF and pain remains unknown. Phospholipase A2 Group VII (PLA2G7) hydrolyzes PAF to eliminate PAF activity. The present study investigated the association between the PLA2G7 rs1051931 nonsynonymous polymorphism (T/C, Val379Ala), which decreases the PAF-degrading activity of PLA2G7 in plasma, and postoperative pain-related phenotypes in humans. The study included 303 patients who underwent sagittal split ramus osteotomy at Tokyo Dental College and were assessed f

SUBMITTER: Hayashi M 

PROVIDER: S-EPMC12071393 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature