Autoantibody Profiling in Ulcerative Colitis: Identification of Early Immune Signatures and Disease-Associated Antigens for Improved Diagnosis and Monitoring.

ABSTRACT: Ulcerative colitis (UC) is a major form of inflammatory bowel disease (IBD) characterised by chronic immune-mediated inflammation. While serological biomarkers for IBD diagnosis and differentiation have been explored, autoantibody-based profiling remains underdeveloped. This study aimed to elucidate antibody signatures in manifested and pre-diagnostic UC patients compared to controls using a high-content protein microarray. Serum and plasma samples from manifested and pre-diagnostic UC cohorts were analysed using AIT's 16k protein microarray, presenting 6369 human proteins. The pre-diagnostic cohort, consisting of 33 UC cases and 33 controls, included longitudinal samples collected before diagnosis, while the severe UC cohort, comprising 49 severe UC patients and 23 controls, included indi

SUBMITTER: Weinhaeusel A 

PROVIDER: S-EPMC12072058 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature